The narrator marrying Isis, their break-up, his adventures, and their reunification may symbolize a spiritual path connecting a seeker to his spirit-soul.
Santana not only describes the world of opposites and suffering, but also hints at a way out. The solution is already present, if only we learn to perceive it.
Oh Sister, like many Dylan songs, can be interpreted on various levels: a relationship of siblings, a love affair, possibly with biographical references? From a spiritual perspective, it may be the spirit aspect addressing the soul aspect in man.
Cohen's Ballad of the Absent Mare is the most spiritual rock and pop song I have encountered because it describes the full path rather than certain aspects.
Love songs are well suited to relate to several levels of understanding: from erotic references to the longing for a companion, a soul mate, up to inner processes of soul and spirit that use worldly love merely as an analogy.